Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 4/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7335766 | 0.85 | CYP19A1 (0.42) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL9491787 | 0.85 | CYP19A1 (0.68) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL402666 | 0.80 | ALDH1A1 (0.58) | CYP19A1ALDH1A1CALM1AKR1B1GRIN2D | |
| SCHEMBL5315445 | 0.79 | TAAR1 (0.67) | IDO1AGXTTAAR1 | |
| SCHEMBL427550 | 0.78 | CYP19A1 (0.55) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL7558508 | 0.76 | CYP19A1 (0.53) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL16453478 | 0.76 | CYP19A1 (0.53) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL153674 | 0.76 | TAAR1 (0.64) | CYP19A1ALDH1A1CALM1AKR1B1TSHR | |
| SCHEMBL919408 | 0.76 | AKR1B1 (0.55) | CYP19A1ALDH1A1CALM1AKR1B1DAO | |
| SCHEMBL9830950 | 0.76 | CYP19A1 (0.59) | CYP19A1ALDH1A1CALM1AKR1B1DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020049199-A1 | N-linked carbamates and ureas of heterocyclic thioesters | GLIAMED, INC. | 2002-04-25 | — | — | US | claimed |
| EP-1021423-A1 | MACROCYCLIC INHIBITORS OF MATRIX METALLOPROTEINASES AND TNF$g(a) SECRETION | Abbott Laboratories (US) | 2000-07-26 | — | — | EP | claimed |
| US-5952320-A | USEFUL IN THE TREATMENT OF DISEASES IN WHICH MATRIX METALLOPROTEINASE PLAY A ROLE; MATRIX METALLOPROTEINASE INHIBITING COMPOSITIONS | ABBOTT LABORATORIES (US) | 1999-09-14 | — | — | US | claimed |
| WO-1998030551-A1 | MACROCYCLIC INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFα SECRETION | ABBOTT LABORATORIES (US) | 1998-07-16 | — | — | WO | claimed |
| EP-0919545-B1 | Benzyloxy substituted aromatics and their use as fungicides | DOW AGROSCIENCES LLC (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-0835865-B1 | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides | DOW AGROSCIENCES LLC (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1050528-B1 | Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds | DOW AGROSCIENCES LLC (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1035122-B1 | Heterocyclic subsituted isoxazolidines and their use as fungicides | DOW AGROSCIENCES LLC (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-0811614-B1 | Benzyloxy substituted aromatics and their use as fungicides and insecticides | DOW AGROSCIENCES LLC (US) | 2002-09-25 | — | — | EP | disclosed |
| US-20020049199-A1 | N-linked carbamates and ureas of heterocyclic thioesters | GLIAMED, INC. | 2002-04-25 | — | — | US | disclosed |
| US-6335367-B1 | Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds | DOW AGROSCIENCES LLC | 2002-01-01 | — | — | US | disclosed |
| EP-0959882-A4 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | HAMILTON GREGORY S (US) | 2001-12-05 | — | — | EP | disclosed |
| CN-1204637-A | Benzyloxy substituted aromatics and their use as fungicides and insecticides | ROHM & HAAS (US) | 1999-01-13 | — | — | CN | disclosed |
| EP-0889024-A1 | Benzyloxy substituted aromatics and their use as fungicides and insecticides | ROHM AND HAAS COMPANY (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0860438-A1 | Fluorine-containing diphenyl acrylamide antimicrobial agents | Shenyang Research Institute of Chemical Industry (CN) | 1998-08-26 | — | — | EP | disclosed |
| WO-1998029117-A1 | N-LINKED UREAS AND CARBAMATES OF HETEROCYCLIC THIOESTERS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-07-09 | — | — | WO | disclosed |
| EP-0835865-A1 | Dihydropyridazinones and pyridazinones and their use as fungicides and insecticides | ROHM AND HAAS COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0811614-A1 | Benzyloxy substituted aromatics and their use as fungicides and insecticides | ROHM AND HAAS COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| EP-0811608-A1 | Benzyloxy substituted aromatics containing an acrylyl moiety and their use as fungicides and insecticides | ROHM AND HAAS COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| US-4147869-A | ADRENERGIC BLOCKING AGENTS FOR TREATMENT OF ANGINA PECTORIS, ARRHYTHMIA AND HYPERTENSION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1979-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049199-A1 | N-linked carbamates and ureas of heterocyclic thioesters | FKBP8, FKBP1A, FKBP3 | CYP19A1 2934/4885ALDH1A1 3491/4885CALM1 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.