Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040086 | 0.75 | MAPT (0.68) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL169467 | 0.75 | MAPT (0.76) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL4620787 | 0.73 | MAPT (1.00) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL21378607 | 0.73 | CYP1A2 (0.68) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL21396319 | 0.71 | MAPT (0.64) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL15924280 | 0.70 | MAPT (0.72) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL2447095 | 0.68 | CYP1A2 (0.60) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL3649105 | 0.68 | HPGD (0.64) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL35210092 | 0.68 | MAPT (0.56) | MAPTCYP1A2CYP3A4NPC1RAB9A | |
| SCHEMBL7398258 | 0.68 | KMT2A (0.54) | CHRNA7MEN1KMT2AGAAHCN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627190-A | TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION, ORGASTROINTESTINAL DISORDERS, 5-HYDROXYTRYPTAMINE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1997-05-06 | — | — | US | disclosed |
| US-5430040-A | Anxiolytic agents, antidepressants, antiserotonine agents; treatment of psychosis, gastrointestinal disorders | G. D. SEARLE & CO. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5280029-A | Containing imidazolo(1,5-a)pyridine | G. D. SEARLE & CO. (US) | 1994-01-18 | — | — | US | disclosed |
| US-5234921-A | Antagonists of the serotonin 5-HT3 receptor; gastrointestinal disorders; antidepressants; drug abuse | G. D. SEARLE & CO. (US) | 1993-08-10 | — | — | US | disclosed |
| US-5227377-A | Serotonin 5-HT3 receptor antagonists | G. D. SEARLE & CO. (US) | 1993-07-13 | — | — | US | disclosed |
| US-5219850-A | Anyiolytic agents, gastrointestinal disorders, antiserotonin agents | G. D. SEARLE & CO. (US) | 1993-06-15 | — | — | US | disclosed |
| US-5196547-A | Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof | G. D. SEARLE & CO. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5137893-A | Anxilytic agents; antidepressants; antiemetics | G. D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |