Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | HCN1 | O60741 | 4/20 | 0.52 |
| ▸ | HCN4 | Q9Y3Q4 | 4/20 | 0.52 |
| ▸ | PREP | P48147 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | HCN3 | Q9P1Z3 | 1/20 | 0.48 |
| ▸ | HCN2 | Q9UL51 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458315 | 0.83 | PREP (0.48) | KMT2APREPHRH3HTR4PRMT5 | |
| SCHEMBL590971 | 0.82 | PREP (0.49) | KMT2APREPHRH3HTR4PRMT5 | |
| SCHEMBL10078783 | 0.79 | HTR4 (0.48) | PREPHRH3HTR4PRMT5WDR77 | |
| SCHEMBL9623178 | 0.75 | HTR4 (0.50) | KMT2ACHRNA7PREPHRH3HTR4 | |
| SCHEMBL7330236 | 0.74 | KMT2A (0.67) | KMT2AHRH3HTR4 | |
| SCHEMBL10288963 | 0.73 | HDAC1 (0.62) | KMT2AMEN1 | |
| SCHEMBL9078900 | 0.73 | CNR2 (0.50) | KMT2AMEN1PREPHRH3HTR4 | |
| SCHEMBL12903051 | 0.73 | PBRM1 (0.60) | KMT2AMEN1 | |
| SCHEMBL23162787 | 0.72 | ADAM17 (0.59) | PREPHTR4 | |
| SCHEMBL29988626 | 0.72 | ADAM17 (0.59) | PREPHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612366-A | USEFUL IN TREATMENT OF CENTRAL NERVOUS SYSTEM AND GASTROINTESTINAL MOTILITY DISORDERS | G. D. SEARLE & CO. (US) | 1997-03-18 | — | — | US | disclosed |
| US-5516782-A | FOR TREATMENT OF ANXIETY, PSYCHOSES, DEPRESSION OR GASTROINTESTINAL MOTILITY DISTURBANCES | G. D. SEARLE & CO. (US) | 1996-05-14 | — | — | US | disclosed |
| US-5318977-A | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G. D. SEARLE & CO. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0528026-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| EP-0504680-A1 | New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents | G.D. Searle & Co. (US) | 1992-09-23 | — | — | EP | disclosed |
| WO-1992015590-A1 | NEW MESO-AZACYCLIC AROMATIC ACID AMIDES AND ESTERS AS NOVEL SEROTONERGIC AGENTS | G.D. SEARLE & CO. (US) | 1992-09-17 | — | — | WO | disclosed |