Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Fenticlor. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 0.69 |
| ▸ | HPGD | P15428 | 7/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.69 |
| ▸ | MEN1 | O00255 | 5/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | HTT | P42858 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.69 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenticlor SCHEMBL669070 | 1.00 | ALOX15 (0.69) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL8365199 | 0.90 | ALOX15 (0.56) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL22074657 | 0.85 | HPGD (0.80) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL23276 | 0.83 | HSD17B10 (1.00) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL29729454 | 0.83 | HSD17B10 (1.00) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL2898956 | 0.81 | HSD17B10 (0.95) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL8863189 | 0.79 | HSD17B10 (0.91) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Triaziquone SCHEMBL3454525 | 0.79 | CYP3A4 (0.43) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL1053679 | 0.78 | HPGD (0.67) | ALOX15HPGDHSD17B10MEN1KMT2A | |
| Fenticlor SCHEMBL318006 | 0.77 | ALOX15 (0.56) | ALOX15HPGDHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580923-B2 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | NORTHWESTERN UNIVERSITY (US) | 2013-11-12 | — | — | US | disclosed |
| US-20120264912-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | NORTHWESTERN UNIVERSITY (US) | 2012-10-18 | — | — | US | disclosed |
| US-8138140-B2 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | NORTHWESTERN UNIVERSITY (US) | 2012-03-20 | — | — | US | disclosed |
| EP-1696945-B1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | UNIV NORTHWESTERN (US) | 2012-01-18 | — | — | EP | disclosed |
| EP-2314305-A2 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | Northwestern University (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20090269847-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | NORTHWESTERN UNIVERSITY (US) | 2009-10-29 | — | — | US | disclosed |
| US-7544661-B2 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | NORTHWESTERN UNIVERSITY (US) | 2009-06-09 | — | — | US | disclosed |
| EP-1696945-A4 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | UNIV NORTHWESTERN (US) | 2007-03-21 | — | — | EP | disclosed |
| EP-1696945-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | NORTHWESTERN UNIVERSITY (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20050209145-A1 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | ENERGY, UNITED STATES DEPARTMENT OF | 2005-09-22 | — | — | US | disclosed |
| WO-2005056039-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | NORTHWESTERN UNIVERSITY (US) | 2005-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090269847-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | HDGF, HDGFL3, IAPP | ALOX15 4321/4885HPGD 4613/4885HSD17B10 4027/4885 |
| US-20120264912-A1 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY | HDGF, HDGFL3, IAPP | ALOX15 4321/4885HPGD 4613/4885HSD17B10 4027/4885 |
| US-20050209145-A1 | Self-assembling peptide amphiphiles and related methods for growth factor delivery | HDGF, HDGFL3, IAPP | ALOX15 4321/4885HPGD 4613/4885HSD17B10 4027/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.