Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334597 | 0.87 | MAOB (0.61) | MAOBNPSR1MAPTTSHRUSP2 | |
| SCHEMBL7329517 | 0.87 | MEN1 (0.65) | MAOBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL4754213 | 0.86 | MAOB (0.74) | MAOBNPSR1MAPTTSHRUSP2 | |
| SCHEMBL4750972 | 0.85 | MAOB (0.80) | MAOBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL8989066 | 0.83 | NPSR1 (0.67) | MAOBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL19464784 | 0.81 | SLC6A7 (0.60) | MAOBMAPTTSHRUSP2KMT2A | |
| SCHEMBL27489578 | 0.81 | NPSR1 (0.70) | MAOBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL31350986 | 0.80 | MAOB (1.00) | MAOBCACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL18397576 | 0.79 | HPGD (0.70) | KMT2AMEN1CDK4CCND1ALDH1A1 | |
| SCHEMBL16598693 | 0.79 | MAOB (0.74) | MAOBNPSR1MAPTTSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| EP-0693062-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LTD. (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |
| WO-1994024116-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |