Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336017 | 0.87 | MAOB (0.65) | MAOBUSP2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7329517 | 0.84 | MEN1 (0.65) | MAOBUSP2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4754213 | 0.78 | MAOB (0.74) | MAOBUSP2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL31350855 | 0.78 | MAOB (0.61) | MAOBUSP2TSHRKMT2AALDH1A1 | |
| SCHEMBL19464784 | 0.78 | SLC6A7 (0.60) | MAOBUSP2TSHRSLC6A7KMT2A | |
| SCHEMBL31350986 | 0.78 | MAOB (1.00) | MAOBUSP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27405138 | 0.77 | MAOB (0.60) | MAOBUSP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL31350890 | 0.76 | USP2 (0.80) | MAOBUSP2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL16598693 | 0.76 | MAOB (0.74) | MAOBUSP2CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4753326 | 0.76 | USP2 (0.80) | MAOBUSP2CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545645-A | Heterocyclic derivatives in the treatment of ischaemia and related diseases | SYNTEX PHARMACEUTICALS, LIMITED (GB) | 1996-08-13 | — | — | US | disclosed |
| EP-0693062-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LTD. (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5428037-A | Piperazine derivatives; calcium and sodium channel antagonists | SYNTEX PHARMACEUTICALS, LTD. (GB) | 1995-06-27 | — | — | US | disclosed |
| WO-1994024116-A1 | HETEROCYCLIC DERIVATIVES IN THE TREATMENT OF ISCHAEMIA AND RELATED DISEASES | SYNTEX PHARMACEUTICALS LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |