Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.43 |
| ▸ | QPCT | Q16769 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | VEGFA | P15692 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336073 | 0.86 | QPCT (0.49) | PDE4AQPCTPDE4D | |
| SCHEMBL5964136 | 0.84 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL7329796 | 0.83 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7327462 | 0.82 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7333917 | 0.80 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7396364 | 0.79 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7292161 | 0.79 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL7294704 | 0.77 | PDE4B (0.60) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| Hydrochloric Acid SCHEMBL7290286 | 0.76 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4DVEGFA | |
| SCHEMBL7301150 | 0.74 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4DVEGFA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250700-A | Phosphodiesterase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-05 | — | — | US | disclosed |