Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | ACP3 | P15309 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23343776 | 1.00 | PNMT (0.53) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL2601113 | 0.85 | DAO (0.59) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL255035 | 0.85 | PNMT (0.55) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL15820267 | 0.83 | HTR2A (0.51) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| Ammonia Solution, Strong SCHEMBL27629775 | 0.83 | PNMT (0.53) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL22189207 | 0.83 | PNMT (0.56) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL215226 | 0.82 | PNMT (0.51) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL1535283 | 0.82 | PNMT (0.61) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL22497538 | 0.82 | PNMT (0.51) | PNMTHTR2AHTR2BHTR2CIDO1 | |
| SCHEMBL10157207 | 0.82 | PNMT (0.51) | PNMTHTR2AHTR2BHTR2CIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2650286-A1 | Quinazoline derivatives and therapeutic use thereof | Rexahn Pharmaceuticals, Inc. (US) | 2013-10-16 | — | — | EP | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |