Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | PPOX | P50336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4471027 | 0.87 | TDP1 (0.41) | CRHBPCRHR2EPAS1TDP1MEN1 | |
| SCHEMBL7550828 | 0.80 | TSHR (0.49) | MEN1KMT2APTPN1TSHRALDH1A1 | |
| SCHEMBL4003073 | 0.78 | EPAS1 (0.41) | EPAS1TDP1MEN1KMT2ATTR | |
| SCHEMBL31090845 | 0.77 | PDE7A (0.49) | EPAS1KMT2APTPN1TSHRALDH1A1 | |
| SCHEMBL6816625 | 0.77 | PDE7A (0.49) | EPAS1KMT2APTPN1TSHRALDH1A1 | |
| SCHEMBL810810 | 0.77 | TSHR (0.49) | TDP1MEN1KMT2APTPN1TSHR | |
| SCHEMBL31090816 | 0.77 | TSHR (0.49) | TDP1MEN1KMT2APTPN1TSHR | |
| SCHEMBL7392580 | 0.77 | TSHR (0.40) | CRHBPCRHR2TDP1MEN1KMT2A | |
| SCHEMBL2050119 | 0.77 | TDP1 (0.39) | CRHBPCRHR2EPAS1TDP1THRB | |
| SCHEMBL8548365 | 0.76 | TDP1 (0.50) | TDP1MEN1KMT2ATTRALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674620-A1 | TRYPTAMINE ANALOGUES AS 5-HT 1?-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014771-A1 | TRYPTAMINE ANALOGUES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |