Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810810 | 0.91 | TSHR (0.49) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL31090816 | 0.91 | TSHR (0.49) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL40551 | 0.84 | TDP1 (0.49) | L3MBTL1ALDH1A1MAPTPTPN1KMT2A | |
| SCHEMBL4471027 | 0.84 | TDP1 (0.41) | TSHRCYP3A4L3MBTL1ALDH1A1LMNA | |
| SCHEMBL3434984 | 0.83 | PTPN1 (0.46) | ALDH1A1MAPTPTPN1MAPK1KMT2A | |
| SCHEMBL29866230 | 0.80 | TSHR (0.53) | TSHRCYP3A4L3MBTL1ALDH1A1LMNA | |
| SCHEMBL29866226 | 0.80 | TSHR (0.53) | TSHRCYP3A4L3MBTL1ALDH1A1LMNA | |
| SCHEMBL7336648 | 0.80 | CRHBP (0.40) | TSHRCYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL26933718 | 0.80 | HSP90AA1 (0.38) | TSHRCYP3A4LMNAMAPTPTPN1 | |
| SCHEMBL3352532 | 0.79 | VCAM1 (0.54) | TSHRCYP3A4ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657427-B1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMA (JP) | 2002-06-19 | — | — | EP | disclosed |
| US-5719152-A | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5496843-A | Tricyclic indole-2-carboxylic acid derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0657427-A1 | Tricyclic indole-2-carboxylic acid derivatives being selective antagonists of the NMDA receptor | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0627434-A1 | Tricyclic quinoxalinedione derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-12-07 | — | — | EP | disclosed |