Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6650 | 0.92 | KCNA3 (0.43) | MAPTHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7377 | 0.92 | LMNA (0.44) | MAPTKCNA3CYP2C9ABCC3ABCC4 | |
| SCHEMBL6315 | 0.91 | KCNA3 (0.43) | MAPTKCNA3POLBCYP2C9ABCC3 | |
| SCHEMBL6287 | 0.90 | CYP2C9 (0.49) | MAPTPOLBCYP2C9ABCC3ABCC4 | |
| SCHEMBL6804 | 0.87 | OPRM1 (0.47) | MAPTCYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL2112 | 0.87 | KCNA3 (0.44) | KCNA3CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL18597761 | 0.86 | ABCC3 (0.41) | CYP2C9ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL6459 | 0.85 | TSHR (0.47) | MAPTKCNA3CYP2C9ABCC3ABCC4 | |
| SCHEMBL1341 | 0.85 | ABCC3 (0.43) | KCNA3CYP2C9ABCC3ABCC4ABCB11 | |
| SCHEMBL6318 | 0.85 | ABCC3 (0.43) | KCNA3CYP2C9ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |