Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337082 | 1.00 | CTSK (0.50) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL7327404 | 0.94 | CTSK (0.52) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL7327391 | 0.94 | CTSK (0.52) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL9806119 | 0.89 | CTSK (0.46) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL9806110 | 0.83 | CTSK (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL27709473 | 0.77 | CTSK (0.48) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL7337095 | 0.77 | CTSK (0.47) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL9514563 | 0.76 | CTSK (0.45) | CTSKCTSSCTSLCTSBAAK1 | |
| SCHEMBL7337088 | 0.76 | CTSK (0.53) | CTSKCTSSHDAC4HDAC1HDAC6 | |
| SCHEMBL29111948 | 0.74 | HDAC4 (0.56) | CTSKCTSSHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5095119-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-03-10 | — | — | US | disclosed |
| US-5075451-A | Pyrrolimidazolones useful as renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5023338-A | Renin inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-06-11 | — | — | US | disclosed |