Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.59 |
| ▸ | CA12 | O43570 | 4/20 | 0.49 |
| ▸ | CA2 | P00918 | 4/20 | 0.49 |
| ▸ | CA9 | Q16790 | 4/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | NFKBIA | P25963 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6720672 | 0.88 | PTGES (0.57) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL11493406 | 0.85 | PTGES (0.47) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL11487687 | 0.84 | CHEK1 (0.54) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL7337154 | 0.81 | PTGES (0.47) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL7342661 | 0.80 | PTGES (0.56) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL30940077 | 0.80 | PTGES (0.56) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL11490983 | 0.77 | PTGES (0.47) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL30873089 | 0.76 | CA12 (0.61) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL6191881 | 0.76 | CA12 (0.61) | PTGESCA12CA2CA9CA1 | |
| SCHEMBL7337339 | 0.74 | NPC1 (0.36) | PTGESKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |
| US-4233299-A | ANTIINFLAMMATORY AGENTS, ANTIPYRETICS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-11-11 | — | — | US | disclosed |