Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.50 |
| ▸ | F2 | P00734 | 6/20 | 0.47 |
| ▸ | PLG | P00747 | 6/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.47 |
| ▸ | PLAT | P00750 | 5/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.35 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7338215 | 0.95 | PLAU (0.46) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7337119 | 0.87 | PLAU (0.67) | PLAUF2PLGKLKB1PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7338206 | 0.82 | PLAU (0.60) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7339262 | 0.80 | PLAU (0.73) | PLAUF2PLGKLKB1PRSS1 | |
| Trifluoroacetic Acid SCHEMBL7336839 | 0.75 | PLAU (0.65) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL8237224 | 0.74 | PLAU (0.48) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL5598221 | 0.74 | PLAU (0.38) | PLAUNAMPTKMT2AMEN1RAB9A | |
| SCHEMBL8230065 | 0.72 | PLAU (0.43) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7344225 | 0.71 | PLAU (0.55) | PLAUF2PLGKLKB1PRSS1 | |
| SCHEMBL7344380 | 0.71 | PLAU (0.66) | PLAUF2PLGKLKB1PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |