Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598037 | 0.82 | ADRA1D (0.37) | DRD3DRD2MEN1RAB9AKMT2A | |
| SCHEMBL7337119 | 0.78 | PLAU (0.67) | PLAU | |
| Trifluoroacetic Acid SCHEMBL7338206 | 0.74 | PLAU (0.60) | PLAU | |
| SCHEMBL7337131 | 0.74 | PLAU (0.50) | PLAUMEN1RAB9AKMT2ANAMPT | |
| SCHEMBL8474346 | 0.73 | PLAU (0.59) | PLAUDRD3DRD2HTR1AOPRM1 | |
| SCHEMBL8237224 | 0.72 | PLAU (0.48) | PLAUMEN1RAB9AKMT2A | |
| SCHEMBL24192442 | 0.64 | CHRNB2 (0.38) | MEN1RAB9AKMT2ANAMPT | |
| SCHEMBL22461453 | 0.64 | KRAS (0.42) | — | |
| SCHEMBL22460911 | 0.64 | CYP1A2 (0.35) | OPRK1RAB9AKMT2A | |
| SCHEMBL4200544 | 0.64 | CYP2C9 (0.45) | DRD3DRD2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007072041-A1 | THERAPEUTIC COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |