Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.66 |
| ▸ | MMP2 | P08253 | 11/20 | 0.63 |
| ▸ | MMP3 | P08254 | 10/20 | 0.63 |
| ▸ | MMP9 | P14780 | 5/20 | 0.58 |
| ▸ | MMP8 | P22894 | 5/20 | 0.58 |
| ▸ | MMP7 | P09237 | 4/20 | 0.58 |
| ▸ | FCER2 | P06734 | 1/20 | 0.58 |
| ▸ | REN | P00797 | 2/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337403 | 0.90 | MME (0.60) | MMP1MMP2MMP9MMP7REN | |
| SCHEMBL7589289 | 0.88 | MMP1 (0.64) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7404527 | 0.87 | MMP1 (0.65) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7367573 | 0.86 | MMP1 (0.67) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7594281 | 0.86 | MMP1 (0.61) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7377811 | 0.84 | MMP1 (0.74) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7426614 | 0.84 | MMP1 (0.74) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6411607 | 0.84 | MMP1 (0.74) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7404473 | 0.83 | MMP1 (0.63) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL6416810 | 0.82 | MMP1 (0.65) | MMP1MMP2MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826000-B1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | DARWIN DISCOVERY LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-6110896-A | TRIPEPTIDYL DERIVATIVES HAVING A MERCAPTO OR ACYLTHIO GROUP AND WHICH ARE AMIDES; UTILITY AS MATRIX METALLOPROTEASE OR TNF INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2000-08-29 | — | — | US | disclosed |