Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 9/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.42 |
| ▸ | TMPRSS11D | O60235 | 2/20 | 0.41 |
| ▸ | XIAP | P98170 | 3/20 | 0.41 |
| ▸ | ACE | P12821 | 4/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346760 | 0.92 | F2 (0.54) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL9073832 | 0.92 | F2 (0.54) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL7338554 | 0.91 | F2 (0.53) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL7341166 | 0.89 | F2 (0.53) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL7334169 | 0.89 | F2 (0.53) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL7335771 | 0.89 | F2 (0.51) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL9076469 | 0.88 | F2 (0.51) | F2PRSS1PRSS2PRSS3TMPRSS11D | |
| SCHEMBL7337918 | 0.88 | F2 (0.51) | F2PRSS1TMPRSS11DXIAPOPRM1 | |
| SCHEMBL7337478 | 0.87 | F2 (0.53) | F2PRSS1TMPRSS11DXIAP | |
| SCHEMBL9075674 | 0.87 | F2 (0.51) | F2PRSS1PRSS2PRSS3TMPRSS11D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | claimed |
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |