Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343435 | 0.88 | CACNA2D1 (0.46) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| Oxalic Acid SCHEMBL9282086 | 0.87 | ALDH1A1 (0.45) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7346193 | 0.84 | HDAC6 (0.41) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7348298 | 0.79 | POLB (0.45) | ALDH1A1LMNATP53MAPTKMT2A | |
| SCHEMBL7350057 | 0.79 | ALDH1A1 (0.56) | ALDH1A1LMNATP53MEN1MAPT | |
| SCHEMBL7343072 | 0.78 | CACNA2D1 (0.53) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7349855 | 0.75 | CACNA2D1 (0.43) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7348481 | 0.73 | NPC1 (0.46) | ALDH1A1LMNATP53MAPTKMT2A | |
| SCHEMBL7349008 | 0.71 | CACNA2D1 (0.40) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL209154 | 0.70 | DRD4 (0.61) | ALDH1A1CACNA2D1CACNA1BCACNB1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | claimed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | claimed |
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |