Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350057 | 0.95 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL7339243 | 0.79 | ALDH1A1 (0.50) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL7346193 | 0.77 | HDAC6 (0.41) | ALDH1A1HTTKMT2APOLBMAPT | |
| SCHEMBL7343435 | 0.74 | CACNA2D1 (0.46) | RAB9AALDH1A1HTTNPSR1KDM4E | |
| SCHEMBL7337534 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HTTKMT2ANPSR1MAPT | |
| SCHEMBL7348298 | 0.73 | POLB (0.45) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL7342419 | 0.73 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL7481751 | 0.73 | ALDH1A1 (0.55) | NPC1RAB9AALDH1A1KMT2APOLB | |
| SCHEMBL6119612 | 0.73 | SRD5A2 (0.48) | ALDH1A1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL4490079 | 0.73 | MPO (0.53) | NPC1RAB9AALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |