Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7347292 | 0.94 | LTA4H (0.40) | LTA4HNPC1OPRM1OPRD1OPRK1 | |
| SCHEMBL7346567 | 0.94 | LTA4H (0.40) | LTA4HACHEHRH3KCNH2 | |
| SCHEMBL7348815 | 0.92 | LTA4H (0.35) | LTA4HNPC1OPRM1OPRD1OPRK1 | |
| SCHEMBL7340174 | 0.92 | LTA4H (0.35) | LTA4HNPC1NR1H4OPRM1OPRD1 | |
| SCHEMBL7342835 | 0.84 | LTA4H (0.42) | LTA4HNPC1OPRM1OPRD1OPRK1 | |
| SCHEMBL7341504 | 0.84 | LTA4H (0.42) | LTA4HNPC1OPRM1OPRD1OPRK1 | |
| SCHEMBL7339312 | 0.84 | NR1H4 (0.34) | NR1H4 | |
| SCHEMBL7338815 | 0.83 | HTT (0.43) | — | |
| SCHEMBL7347297 | 0.82 | LTA4H (0.37) | LTA4HNPC1NR1H4OPRM1OPRD1 | |
| SCHEMBL7341051 | 0.81 | NR1H4 (0.34) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | claimed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | claimed |
| EP-0699680-B1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SANOFI SYNTHELABO (FR) | 2000-03-08 | — | — | EP | disclosed |
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| EP-0699680-A1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1996-03-06 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |