Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337662 | 0.94 | LTA4H (0.44) | LTA4HOPRM1OPRD1OPRK1NPC1 | |
| SCHEMBL7346567 | 0.88 | LTA4H (0.40) | LTA4HHTR2C | |
| SCHEMBL7348815 | 0.86 | LTA4H (0.35) | LTA4HOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL7340174 | 0.86 | LTA4H (0.35) | LTA4HOPRM1OPRD1OPRK1NPC1 | |
| SCHEMBL7347297 | 0.83 | LTA4H (0.37) | LTA4HOPRM1OPRD1OPRK1NPC1 | |
| SCHEMBL7342835 | 0.81 | LTA4H (0.42) | LTA4HOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL7338815 | 0.80 | HTT (0.43) | HTTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7341504 | 0.79 | LTA4H (0.42) | LTA4HOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL7339312 | 0.79 | NR1H4 (0.34) | — | |
| SCHEMBL7341051 | 0.76 | NR1H4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |