Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.32 |
| ▸ | GCGR | P47871 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7335002 | 0.99 | SLC6A2 (0.33) | SLC6A2MAPK14GCGRBRAF | |
| SCHEMBL8050077 | 0.93 | MAPT (0.33) | SLC6A2MAPK14GCGRBRAFALDH1A1 | |
| Hydrochloric Acid SCHEMBL8056275 | 0.92 | MAPT (0.33) | SLC6A2MAPK14GCGRALDH1A1MAPT | |
| SCHEMBL8049764 | 0.90 | MAPK14 (0.33) | MAPK14GCGRALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL8050473 | 0.89 | MAPK14 (0.33) | MAPK14GCGRALDH1A1LMNAPOLB | |
| SCHEMBL8051657 | 0.87 | MPO (0.35) | BRAFALDH1A1LMNAMAPT | |
| SCHEMBL8053584 | 0.86 | SLC6A2 (0.35) | SLC6A2MAPK14BRAFALDH1A1LMNA | |
| SCHEMBL8056707 | 0.85 | SLC6A2 (0.41) | SLC6A2GCGRLMNAMAPT | |
| Hydrochloric Acid SCHEMBL8052007 | 0.85 | SLC6A2 (0.34) | SLC6A2MAPK14BRAFALDH1A1LMNA | |
| SCHEMBL8054044 | 0.84 | LATS1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509402-B1 | Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-01-07 | — | — | EP | claimed |
| EP-0509402-A1 | Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-21 | — | — | EP | claimed |
| US-6022880-A | Substituted pyridylamino indoles | HOECHST MARION ROUSSEL, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0509402-B1 | Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5328920-A | Alleviating memory dysfunctions | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-07-12 | — | — | US | disclosed |
| US-5177088-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0509402-A1 | Substituted 3-(Pyridinylamino)-indoles and benzo[b]thiophenes, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-10-21 | — | — | EP | disclosed |