Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338597 | 0.87 | KCNH2 (0.38) | LMNATP53KCNH2HTTALDH1A1 | |
| SCHEMBL7333092 | 0.86 | TRPM8 (0.41) | LMNATP53TRPM8POLBMEN1 | |
| SCHEMBL7339601 | 0.84 | KCNH2 (0.44) | LMNAKCNH2HTTALDH1A1L3MBTL1 | |
| SCHEMBL7343282 | 0.82 | KCNH2 (0.39) | LMNAKCNH2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL7336464 | 0.82 | KCNH2 (0.45) | LMNAKCNH2HTTALDH1A1L3MBTL1 | |
| SCHEMBL7336180 | 0.82 | KCNH2 (0.45) | LMNATP53KCNH2HTTALDH1A1 | |
| SCHEMBL7335763 | 0.80 | KCNH2 (0.43) | LMNATP53KCNH2HTTALDH1A1 | |
| SCHEMBL7344178 | 0.80 | KCNH2 (0.43) | LMNAKCNH2HTTALDH1A1L3MBTL1 | |
| SCHEMBL7345118 | 0.79 | KCNH2 (0.50) | KCNH2HTTALDH1A1L3MBTL1POLB | |
| SCHEMBL7335864 | 0.77 | TRPM8 (0.39) | LMNATP53HTTALDH1A1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0964853-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| WO-1998035946-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |