Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339601 | 0.91 | KCNH2 (0.44) | KCNH2KDM4EKMT2AALDH1A1HTT | |
| SCHEMBL7335763 | 0.91 | KCNH2 (0.43) | KCNH2RXFP1KDM4EGAATP53 | |
| SCHEMBL7336464 | 0.90 | KCNH2 (0.45) | KCNH2RXFP1KDM4EKMT2AALDH1A1 | |
| SCHEMBL7344178 | 0.86 | KCNH2 (0.43) | KCNH2KDM4EKMT2AALDH1A1HTT | |
| SCHEMBL7335484 | 0.86 | THRB (0.38) | KCNH2TP53ALDH1A1MAPTPOLB | |
| SCHEMBL7338032 | 0.82 | LMNA (0.43) | KCNH2KDM4ETP53KMT2AALDH1A1 | |
| SCHEMBL7345118 | 0.82 | KCNH2 (0.50) | KCNH2KDM4EKMT2AALDH1A1HTT | |
| SCHEMBL7343282 | 0.81 | KCNH2 (0.39) | KCNH2KDM4EGAAKMT2AALDH1A1 | |
| SCHEMBL7367752 | 0.78 | KCNH2 (0.43) | KCNH2RXFP1KDM4ETP53KMT2A | |
| SCHEMBL7334227 | 0.78 | KCNH2 (0.42) | KCNH2KDM4EGAAKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103744-A | ADMINISTERING TO THE PATIENT A DOPAMINE AUTORECEPTOR AGONISTS FOR THE TREATMENT OF SCHIZOPHRENIA, PARKINSON,S DISEASE, TOURETTE,S SYNDROM, ALCOHOLISM AND DRUG ADDICTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| EP-0964854-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0964853-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| US-5990144-A | TREATING PARKINSON'S DISEASE, TOURETTE'S SYNDROME, SCHIZOPHRENIA, AND ALCOHOL AND DRUG ADDICTION; DOPAMINERGIC PROPERTIES; SIDE-EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-23 | — | — | US | disclosed |
| US-5972958-A | 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998035946-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-ONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |
| WO-1998035947-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |