Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | YWHAZ | P63104 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338203 | 1.00 | HSD17B3 (0.42) | HSD17B3MAOAMAOBCYP2D6CYP1B1 | |
| SCHEMBL7329830 | 0.88 | NPC1 (0.44) | MAOAMAOBCYP1B1ATMCYP1A2 | |
| SCHEMBL7365039 | 0.88 | MAOB (0.44) | MAOAMAOBCYP2D6CYP1B1CYP1A2 | |
| SCHEMBL7365035 | 0.88 | MAOB (0.44) | MAOAMAOBCYP2D6CYP1B1CYP1A2 | |
| SCHEMBL7329824 | 0.88 | NPC1 (0.44) | MAOAMAOBCYP1B1ATMCYP1A2 | |
| SCHEMBL7339064 | 0.84 | HCAR2 (0.47) | MAOAMAOBCYP2D6CYP1B1CYP1A2 | |
| SCHEMBL7330544 | 0.81 | KDM4E (0.44) | ALDH1A1DCTPP1LMNAKMT2AKDM4E | |
| SCHEMBL7330541 | 0.81 | KDM4E (0.44) | ALDH1A1DCTPP1LMNAKMT2AKDM4E | |
| SCHEMBL7336228 | 0.81 | LMNA (0.52) | MAOAMAOBCYP1B1CYP1A1ALDH1A1 | |
| SCHEMBL7336232 | 0.81 | LMNA (0.52) | MAOAMAOBCYP1B1CYP1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191124-B1 | VIRICIDES | PHARMACIA & UPJOHN COMPANY | 2001-02-20 | — | — | US | disclosed |
| EP-0757692-A1 | METHANOL DERIVATIVES FOR TREATMENT OF RETROVIRAL INFECTIONS ESPECIALLY HIV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029922-A1 | METHANOL DERIVATIVES FOR TREATMENT OF RETROVIRAL INFECTIONS ESPECIALLY HIV INFECTIONS | PHARMACIA & UPJOHN COMPANY (US) | 1995-11-09 | — | — | WO | disclosed |