Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 5/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL868812 | 0.98 | HPGD (0.42) | HPGDALOX15SLC18A3PABPC1APOBEC3A | |
| Bromide SCHEMBL340045 | 0.95 | HPGD (0.41) | HPGDALOX15SLC18A3PABPC1APOBEC3A | |
| Water SCHEMBL1358129 | 0.95 | HPGD (0.41) | HPGDALOX15SLC18A3PABPC1APOBEC3A | |
| SCHEMBL10390898 | 0.91 | HPGD (0.39) | HPGDALOX15SLC18A3PABPC1APOBEC3A | |
| Hydrochloric Acid SCHEMBL3653366 | 0.86 | HPGD (0.46) | HPGDALOX15PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL14790594 | 0.84 | — | — | |
| SCHEMBL13197525 | 0.84 | HPGD (0.47) | HPGDALOX15PABPC1APOBEC3AAPOBEC3G | |
| Bromide SCHEMBL830312 | 0.82 | HPGD (0.46) | HPGDALOX15PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL9935792 | 0.82 | HPGD (0.47) | HPGDALOX15PABPC1APOBEC3AAPOBEC3G | |
| SCHEMBL4893881 | 0.79 | SLC18A3 (0.47) | SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194605-A | Treatment of hypertension, hyperaldosteronism, congestive heart failure, glaucoma | MERCK & CO., INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0518676-A2 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |
| EP-0432975-A1 | Cyclic renin inhibitors | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | disclosed |