Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.60 |
| ▸ | EDNRB | P24530 | 4/20 | 0.60 |
| ▸ | PPARG | P37231 | 6/20 | 0.52 |
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339368 | 0.99 | EDNRA (0.61) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL8789773 | 0.90 | EDNRA (0.58) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL8903647 | 0.90 | EDNRA (0.60) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL7329622 | 0.89 | EDNRA (0.57) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL7338441 | 0.89 | EDNRA (0.60) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL7337968 | 0.87 | EDNRA (0.50) | EDNRAEDNRBALDH1A1MAPTTSHR | |
| SCHEMBL7341430 | 0.86 | PPARG (0.49) | EDNRAEDNRBPPARGPPARAALDH1A1 | |
| SCHEMBL7330600 | 0.84 | EDNRA (0.77) | EDNRAEDNRBPPARGPPARA | |
| SCHEMBL8904044 | 0.84 | EDNRA (0.55) | EDNRAEDNRBPPARGPPARAKMT2A | |
| SCHEMBL7339477 | 0.83 | EDNRA (0.59) | EDNRAEDNRBALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| US-5559135-A | TREATMENT OF CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS, ANTIINFLAMMATORY AGENTS OR ANTIASTHMATICS | MERCK & CO., INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5538991-A | TREATMENT OF HYPERTENSION, CARDIOVASCULAR DISORDERS, PROSTATE HYPERPLASIA OR ANTIINFLAMMATORY AGENTS | MERCK & CO., INC. (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1996008487-A1 | ENDOTHELIN ANTAGONISTS BEARING PYRIDYL AMIDES | MERCK & CO., INC. (US) | 1996-03-21 | — | — | WO | disclosed |