Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 5/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.47 |
| ▸ | TACR2 | P21452 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338587 | 1.00 | YAP1 (0.57) | YAP1P2RX7ACEBCL2CACNA1B | |
| SCHEMBL7339092 | 0.96 | YAP1 (0.60) | YAP1ACEBCL2CACNA1BMMP9 | |
| SCHEMBL7339086 | 0.96 | YAP1 (0.60) | YAP1ACEBCL2CACNA1BMMP9 | |
| SCHEMBL7345873 | 0.96 | YAP1 (0.60) | YAP1ACEBCL2CACNA1BMMP9 | |
| SCHEMBL7345875 | 0.96 | YAP1 (0.60) | YAP1ACEBCL2CACNA1BMMP9 | |
| SCHEMBL7344934 | 0.91 | CACNA1B (0.58) | YAP1CACNA1BREN | |
| SCHEMBL7342880 | 0.91 | CACNA1B (0.58) | YAP1CACNA1BREN | |
| SCHEMBL21023244 | 0.91 | CACNA1B (0.58) | YAP1CACNA1BREN | |
| SCHEMBL7345113 | 0.91 | CACNA1B (0.58) | YAP1CACNA1BREN | |
| SCHEMBL7344929 | 0.91 | CACNA1B (0.58) | YAP1CACNA1BREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | claimed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |