Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.33 |
| ▸ | CDK1 | P06493 | 7/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.33 |
| ▸ | GSK3B | P49841 | 7/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735401 | 0.87 | OPRM1 (0.39) | MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL734846 | 0.86 | KDM4E (0.33) | MEN1KMT2AKIF11HTR2AHTR2C | |
| SCHEMBL733828 | 0.84 | OPRM1 (0.40) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL734534 | 0.84 | OPRM1 (0.39) | MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL734337 | 0.83 | ALOX5 (0.41) | MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL735115 | 0.83 | MEN1 (0.37) | MEN1KMT2ACCNB2CDK1CCNB1 | |
| SCHEMBL1120241 | 0.78 | MEN1 (0.45) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL733086 | 0.77 | OPRM1 (0.45) | MEN1KMT2AKIF11CCNB2CDK1 | |
| SCHEMBL733091 | 0.75 | MEN1 (0.40) | MEN1KMT2AKIF11 | |
| SCHEMBL733092 | 0.75 | MEN1 (0.40) | MEN1KMT2AKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | claimed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | claimed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | claimed |
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | MEN1 2253/4885KMT2A 2453/4885KIF11 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.