Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342447 | 0.90 | HDAC8 (0.57) | POLBCA12CA9ALDH1A1MAPT | |
| SCHEMBL7274072 | 0.87 | HDAC8 (0.67) | POLBALDH1A1KMT2AHDAC8HDAC3 | |
| SCHEMBL14594063 | 0.87 | KMT2A (0.60) | POLBCA12CA9ALDH1A1KMT2A | |
| SCHEMBL135305 | 0.85 | CA12 (0.66) | POLBCA12CA9ALDH1A1MAPT | |
| SCHEMBL30098360 | 0.85 | CA12 (0.66) | POLBCA12CA9ALDH1A1MAPT | |
| SCHEMBL8118590 | 0.82 | ALDH1A1 (0.55) | POLBCA12CA9ALDH1A1KMT2A | |
| SCHEMBL4403950 | 0.82 | ALDH1A1 (0.55) | POLBCA12CA9ALDH1A1KMT2A | |
| SCHEMBL11453214 | 0.82 | HPGD (0.55) | POLBALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL29452030 | 0.81 | ALDH1A1 (0.54) | POLBCA12CA9ALDH1A1KMT2A | |
| SCHEMBL29620255 | 0.81 | KMT2A (0.56) | POLBCA12CA9ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4849436-A | TREATMENT OF CARDIOVASCULAR DISORDERS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-07-18 | — | — | US | disclosed |
| EP-0259462-A1 | 1,4-DIHYDROPYRIDINES | Whitby Research Incorporated (US) | 1988-03-16 | — | — | EP | disclosed |
| WO-1987005512-A1 | 1,4-DIHYDROPYRIDINES | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1987-09-24 | — | — | WO | disclosed |