Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.49 |
| ▸ | TMPRSS15 | P98073 | 12/20 | 0.49 |
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | CPA1 | P15085 | 1/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336254 | 0.92 | PRSS1 (0.50) | CA1CA2PRSS1TMPRSS15ACE | |
| SCHEMBL7332560 | 0.85 | CA2 (0.47) | CA1CA2ITGB3ITGA2BPRSS1 | |
| SCHEMBL7332670 | 0.84 | CA2 (0.50) | CA1CA2ITGB3ITGA2BPRSS1 | |
| SCHEMBL7298590 | 0.83 | PRSS1 (0.47) | CA1CA2ITGB3ITGA2BPRSS1 | |
| SCHEMBL7332802 | 0.83 | PRSS1 (0.52) | ITGB3ITGA2BPRSS1TMPRSS15 | |
| SCHEMBL10954969 | 0.83 | MME (0.61) | CA1CA2ACEMMECPA1 | |
| SCHEMBL7338778 | 0.82 | ITGB3 (0.46) | CA1CA2ITGB3ITGA2BPRSS1 | |
| SCHEMBL9829550 | 0.81 | MME (0.58) | CA1CA2ACEMMECPA1 | |
| SCHEMBL9829553 | 0.81 | MME (0.58) | CA1CA2ACEMMECPA1 | |
| SCHEMBL7331194 | 0.80 | BACE1 (0.44) | PRSS1TMPRSS15ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | claimed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |