Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347469 | 0.92 | ITGB3 (0.40) | ITGB3ITGA2BGAASMN1; SMN2ITGAV | |
| SCHEMBL7339438 | 0.88 | L3MBTL1 (0.39) | ITGB3ITGA2BGAASMN1; SMN2ITGAV | |
| SCHEMBL7348081 | 0.84 | ITGB3 (0.43) | ITGB3ITGA2BSMN1; SMN2ITGAVL3MBTL1 | |
| SCHEMBL7337027 | 0.83 | RXFP1 (0.43) | ITGB3ITGA2BSMN1; SMN2ITGAVL3MBTL1 | |
| SCHEMBL7348024 | 0.83 | ITGB3 (0.42) | ITGB3ITGA2BSMN1; SMN2ITGAVL3MBTL1 | |
| SCHEMBL7340459 | 0.83 | ITGB3 (0.40) | ITGB3ITGA2BGAASMN1; SMN2ITGAV | |
| SCHEMBL7340089 | 0.82 | ANO1 (0.43) | ITGB3ITGA2BITGAVL3MBTL1HTT | |
| SCHEMBL7340337 | 0.81 | ITGB3 (0.41) | ITGB3ITGA2BGAASMN1; SMN2ITGAV | |
| SCHEMBL6777675 | 0.81 | ITGB3 (0.41) | ITGB3ITGA2BGAASMN1; SMN2L3MBTL1 | |
| SCHEMBL7342272 | 0.81 | ITGB3 (0.41) | ITGB3ITGA2BGAASMN1; SMN2ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |