⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1845913 | 1.00 | — | — | |
| SCHEMBL8251229 | 1.00 | — | — | |
| SCHEMBL4929111 | 0.83 | SLC6A2 (0.36) | — | |
| SCHEMBL1846019 | 0.82 | — | — | |
| SCHEMBL1846227 | 0.80 | — | — | |
| SCHEMBL12444568 | 0.78 | GPR84 (0.33) | — | |
| SCHEMBL7123711 | 0.78 | GPR84 (0.33) | — | |
| SCHEMBL5432816 | 0.78 | GPR84 (0.33) | — | |
| SCHEMBL11392320 | 0.78 | SLC6A2 (0.33) | — | |
| SCHEMBL5437330 | 0.78 | TRPA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456185-B1 | Renin inhibitors | ABBOTT LAB (US) | 1995-05-31 | — | — | EP | disclosed |
| US-5344990-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-09-06 | — | — | US | disclosed |
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| US-5275950-A | Process for the preparation of a renin inhibiting compound | ABBOTT LABORATORIES (US) | 1994-01-04 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |