Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | ANPEP | P15144 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.51 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140700 | 0.82 | POLB (0.77) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL463415 | 0.78 | MAPK1 (0.74) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL21928911 | 0.78 | MAPK1 (0.58) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL10108811 | 0.78 | MAPK1 (0.58) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL21834930 | 0.78 | MAPK1 (0.58) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL463419 | 0.77 | MAPK1 (0.57) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL10123862 | 0.77 | TSHR (0.58) | MEN1KMT2AMAPK1OPRK1TSHR | |
| SCHEMBL12065590 | 0.76 | MAPK1 (0.56) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL21034369 | 0.76 | MAPK1 (0.56) | MEN1KMT2APKMMMP2ANPEP | |
| SCHEMBL11833305 | 0.76 | SIGMAR1 (0.59) | MEN1KMT2AMAPK1OPRK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4624961-A | LEARNING ENHANCEMENT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-11-25 | — | — | US | claimed |
| EP-0161074-B1 | GASTROKINETIC AND ANTIEMETIC N-(1-SUBSTITUTED-4,5-DIHYDRO-1H-PYRAZOL-4-YL)BENZAMIDES | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4624961-A | LEARNING ENHANCEMENT | A. H. ROBINS COMPANY, INCORPORATED (US) | 1986-11-25 | — | — | US | disclosed |
| EP-0161074-A1 | Gastrokinetic and antiemetic n-(1-substituted-4,5-dihydro-1h-pyrazol-4-yl)benzamides | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4547518-A | Antiemetic N-(1-substituted-4,5-dihydro-1H-pyrazol-4-yl)benzamides | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-10-15 | — | — | US | disclosed |
| US-4207327-A | N-(4-Pyrazolidinyl)benzamides and their amino precursors | A. H. ROBINS COMPANY, INC. (US) | 1980-06-10 | — | — | US | disclosed |