Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 5/20 | 0.70 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339654 | 1.00 | GAA (1.00) | GAAPOLBGFERKDM4ECTSS | |
| SCHEMBL7338159 | 0.85 | GAA (0.73) | GAAPOLBGFERKDM4ECTSS | |
| SCHEMBL7337674 | 0.85 | GAA (0.73) | GAAPOLBGFERKDM4ECTSS | |
| SCHEMBL11052724 | 0.83 | GAA (0.71) | GAAPOLBGFERKDM4EMAPT | |
| SCHEMBL11049712 | 0.82 | GAA (0.68) | GAAPOLBGFERKDM4EMAPT | |
| SCHEMBL7308857 | 0.80 | GAA (0.66) | GAAPOLBGFERMAPTOPRK1 | |
| SCHEMBL7308861 | 0.80 | GAA (0.66) | GAAPOLBGFERMAPTOPRK1 | |
| SCHEMBL7339296 | 0.79 | GAA (0.64) | GAAPOLBKDM4ECTSSMAPT | |
| SCHEMBL6618585 | 0.79 | GAA (0.64) | GAAPOLBKDM4ECTSSMAPT | |
| SCHEMBL11052233 | 0.78 | GAA (0.64) | GAAPOLBGFERMAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |