Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.61 |
| ▸ | SHBG | P04278 | 1/20 | 0.56 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947478 | 0.89 | MAOB (0.53) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL21860319 | 0.89 | MAOB (0.76) | MAOBSHBGTNKSTYRPTGS1 | |
| SCHEMBL28751161 | 0.89 | MAOB (0.53) | MAOBSHBGTYRPTGS1PTGS2 | |
| SCHEMBL9947474 | 0.89 | MAOB (0.53) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL11711558 | 0.89 | MAOB (0.70) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL11713027 | 0.89 | MAOB (0.74) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL7128324 | 0.88 | MAOB (0.51) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL17427775 | 0.88 | MAOB (0.62) | MAOBSHBGTNKSPARP1TNKS2 | |
| SCHEMBL14231752 | 0.87 | MAOB (0.50) | MAOBSHBGTYRPTGS1PTGS2 | |
| SCHEMBL21860492 | 0.86 | KCNA5 (0.61) | MAOBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-08-09 | — | — | US | disclosed |
| US-7157575-B2 | Substrates for β-lactamase and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070184513-A1 | Substrates for beta-lactamase and uses thereof | CMBL, DBH, NCEH1 | MAOB 180/4885SHBG 2999/4885TNKS 4349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.