Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 6/20 | 0.45 |
| ▸ | EDNRB | P24530 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6958979 | 1.00 | EDNRA (0.45) | EDNRAEDNRBALDH1A1HSD17B10CMA1 | |
| SCHEMBL4631437 | 0.88 | EDNRA (0.57) | EDNRAEDNRBMAPK8TAAR1POLB | |
| SCHEMBL108697 | 0.79 | ALDH1A1 (0.51) | ALDH1A1HSD17B10TAAR1CYP1A2CYP3A4 | |
| SCHEMBL7977314 | 0.77 | ALDH1A1 (0.39) | EDNRAEDNRBALDH1A1HSD17B10MAPK8 | |
| SCHEMBL4631384 | 0.77 | EDNRB (0.44) | EDNRAEDNRBALDH1A1HSD17B10HPGD | |
| SCHEMBL4631380 | 0.77 | EDNRB (0.44) | EDNRAEDNRBALDH1A1HSD17B10HPGD | |
| SCHEMBL4631346 | 0.75 | EDNRA (0.72) | EDNRAEDNRB | |
| SCHEMBL6151316 | 0.73 | EDNRB (0.85) | EDNRAEDNRB | |
| SCHEMBL6956724 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10HPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL4632416 | 0.71 | EDNRB (0.52) | EDNRAEDNRBALDH1A1CMA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |