Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339955 | 0.77 | EDNRA (0.45) | ALDH1A1HSD17B10L3MBTL1EDNRBEDNRA | |
| SCHEMBL6958979 | 0.77 | EDNRA (0.45) | ALDH1A1HSD17B10L3MBTL1EDNRBEDNRA | |
| SCHEMBL6956724 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HSD17B10L3MBTL1MAPTHPGD | |
| SCHEMBL108697 | 0.70 | ALDH1A1 (0.51) | ALDH1A1HSD17B10MAPT | |
| SCHEMBL4631437 | 0.69 | EDNRA (0.57) | EDNRBEDNRAMAPK8POLB | |
| SCHEMBL4631407 | 0.68 | RORB (0.50) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL7404511 | 0.68 | RORB (0.50) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8445530 | 0.64 | ALDH1A1 (0.46) | ALDH1A1HSD17B10L3MBTL1MAPTHPGD | |
| SCHEMBL109195 | 0.63 | TAAR1 (0.64) | ALDH1A1MAPTGAA | |
| SCHEMBL108235 | 0.62 | TAAR1 (0.55) | ALDH1A1HSD17B10MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331637-B1 | N-Alkyl, N-Alkenyl, N-Alkynyl, N-Aryl and N-fused bicyclo or tricyclo thienyl-, furyl-,and Pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin | TEXAS BIOTECHNOLOGY CORPORATION | 2001-12-18 | — | — | US | disclosed |