Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23901663 | 0.89 | IAPP (0.56) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL22211449 | 0.89 | TAAR1 (0.59) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL26343023 | 0.88 | FFAR1 (0.57) | TAAR1FFAR1CASP3CASP7NR3C2 | |
| SCHEMBL334758 | 0.86 | FFAR1 (0.68) | TAAR1FFAR1CASP3CASP7 | |
| SCHEMBL28530595 | 0.86 | TAAR1 (0.47) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL3946037 | 0.85 | TAAR1 (0.46) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL2290 | 0.85 | ALDH1A1 (0.60) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL1447034 | 0.85 | TAAR1 (0.53) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL30344632 | 0.85 | TAAR1 (0.58) | TAAR1FFAR1CASP3CASP7DAO | |
| SCHEMBL2857831 | 0.85 | TAAR1 (0.58) | TAAR1FFAR1CASP3CASP7DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103930407-B | Aminopyrimidine derivatives useful as modulators of kinase activity | 默克专利有限公司 | 2019-02-26 | — | — | CN | disclosed |
| CN-108484511-A | A kind of ligustrazine chalcone compounds and its preparation method and application | 山东大学 | 2018-09-04 | — | — | CN | disclosed |
| CN-106946796-A | Aminopyridine derivative as modulators of kinase activity | 默克专利有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-102791714-B | N-(imidazopyrimidin-7-yl)-heteroarylamide derivatives and their use as PDE10A inhibitors | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | disclosed |
| CN-101553490-A | Bicyclic triazoles as protein kinase modulators | SGX PHARMACEUTICALS INC (US) | 2009-10-07 | — | — | CN | disclosed |
| CN-101268067-A | Indol-3-yl-carbonyl-piperidine-benzimidazole derivatives as V1A receptor antagonists | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | CN | disclosed |
| EP-0771196-B1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1999-12-08 | — | — | EP | disclosed |
| US-5717109-A | CARBOXYCYCLOPROPYL GLYCINE DERIVATIVES; USEFUL FOR TREATMENT OF ACUTE OR CHRONIC NEURODEGENERATIVE CONDITIONS, AND AS ANTIPSYCHOTIC, ANTICONVULSANT, ANALGESIC, ANXIOLYTIC, ANTIDEPRESSANT AND ANTI-EMETIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |