Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | CASP1 | P29466 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7158385 | 0.83 | KDM4E (0.79) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL10860930 | 0.83 | KDM4E (0.79) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL7350838 | 0.83 | HSD17B10 (0.63) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL7343740 | 0.82 | HSD17B10 (0.65) | HSD17B10KDM4EALDH1A1GAAHPGD | |
| SCHEMBL7344603 | 0.82 | KDM4E (0.67) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL7158896 | 0.82 | KDM4E (0.90) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL7160171 | 0.82 | KDM4E (1.00) | HSD17B10KDM4ECASP1ALDH1A1CASP7 | |
| SCHEMBL7348263 | 0.81 | HSD17B10 (0.66) | HSD17B10KDM4EALDH1A1GAAHPGD | |
| SCHEMBL7344861 | 0.81 | HSD17B10 (0.66) | HSD17B10KDM4EALDH1A1GAAHPGD | |
| SCHEMBL7343943 | 0.81 | HSD17B10 (0.66) | HSD17B10KDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |