Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 7/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | CASP1 | P29466 | 3/20 | 0.51 |
| ▸ | CASP7 | P55210 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342224 | 0.85 | HSD17B10 (0.65) | HSD17B10MAPK1MAPTCACNA1BADORA3 | |
| SCHEMBL7350786 | 0.83 | HSD17B10 (0.63) | HSD17B10MAPK1MAPTCACNA1BADORA3 | |
| SCHEMBL7342453 | 0.83 | CACNA1F (0.63) | HSD17B10GAAMAPK1MAPTADORA3 | |
| SCHEMBL7340104 | 0.83 | HSD17B10 (0.63) | HSD17B10MAPK1MAPTCACNA1BADORA3 | |
| SCHEMBL7352182 | 0.83 | HSD17B10 (0.63) | HSD17B10MAPK1MAPTCACNA1BADORA3 | |
| SCHEMBL7347758 | 0.83 | GAA (0.52) | HSD17B10GAAMAPK1MAPTCACNA1B | |
| SCHEMBL7162019 | 0.83 | GAA (0.63) | HSD17B10GAAMAPK1MAPTCACNA1B | |
| SCHEMBL7340301 | 0.83 | HSD17B10 (0.67) | HSD17B10GAAMAPK1MAPTADORA3 | |
| SCHEMBL7349611 | 0.82 | HSD17B10 (0.64) | HSD17B10GAACACNA1BADORA3ALDH1A1 | |
| SCHEMBL10918103 | 0.82 | MAPT (0.70) | MAPK1MAPTADORA3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |