Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11845684 | 0.96 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBCYP4F2CYP4A11KCNA3 | |
| SCHEMBL11847067 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2POLBCYP4F2CYP4A11KCNA3 | |
| SCHEMBL4431144 | 0.89 | SMN1; SMN2 (0.40) | SMN1; SMN2POLBCYP4F2CYP4A11KCNA3 | |
| SCHEMBL4431094 | 0.87 | KYAT1 (0.40) | SMN1; SMN2POLBALDH1A1MEN1KMT2A | |
| SCHEMBL8021565 | 0.86 | SMN1; SMN2 (0.39) | SMN1; SMN2POLBCYP4F2CYP4A11PPID | |
| SCHEMBL11075302 | 0.85 | CYP2C19 (0.40) | SMN1; SMN2OPRM1EBPSIGMAR1ALDH1A1 | |
| SCHEMBL7750624 | 0.83 | SMN1; SMN2 (0.36) | SMN1; SMN2POLBALDH1A1KMT2AMAPT | |
| SCHEMBL7744784 | 0.83 | SMN1; SMN2 (0.34) | SMN1; SMN2POLBCYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL7826967 | 0.82 | KCNA3 (0.52) | SMN1; SMN2POLBCYP4F2CYP4A11KCNA3 | |
| SCHEMBL734030 | 0.81 | KCNN4 (0.42) | SMN1; SMN2POLBKCNA3OPRM1EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399503-B2 | Spirocyclic azaindole derivatives | GRUENENTHAL GMBH (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20090156593-A1 | Spirocyclic Azaindole Derivatives | GRUNENTHAL GMBH (DE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156593-A1 | Spirocyclic Azaindole Derivatives | AZI2, TPMT, AADAC | SMN1; SMN2 4555/4885POLB 4256/4885CYP4F2 415/4885 |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | SMN1; SMN2 4848/4885POLB 3818/4885CYP4F2 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.