Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 14/20 | 0.73 |
| ▸ | MMP9 | P14780 | 12/20 | 0.73 |
| ▸ | MMP3 | P08254 | 10/20 | 0.73 |
| ▸ | MMP7 | P09237 | 10/20 | 0.73 |
| ▸ | MMP13 | P45452 | 14/20 | 0.66 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762105 | 0.88 | MMP1 (0.80) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7341460 | 0.88 | MMP1 (0.80) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6338561 | 0.87 | MMP1 (0.79) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6336332 | 0.85 | MMP1 (0.79) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL7375954 | 0.85 | MMP1 (0.79) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL8314488 | 0.84 | MMP1 (0.71) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6278385 | 0.84 | MMP1 (0.71) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL6266281 | 0.83 | MMP1 (0.75) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL27560678 | 0.81 | MMP1 (0.75) | MMP1MMP9MMP3MMP7MMP13 | |
| SCHEMBL778714 | 0.80 | MMP1 (0.67) | MMP1MMP9MMP3MMP7MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874830-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020824-A1 | METALLOPROTEINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR PHARMACEUTICAL USES, AND METHODS AND INTERMEDIATES USEFUL FOR THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1997-06-12 | — | — | WO | disclosed |