Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBX7 | O95931 | 2/20 | 0.41 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.41 |
| ▸ | CDYL | Q9Y232 | 2/20 | 0.41 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341577 | 0.99 | CBX7 (0.40) | CBX7CDYL2CDYLCDY1; CDY1BPKM | |
| SCHEMBL7342592 | 0.88 | CBX7 (0.42) | CBX7CDYL2CDYLCDY1; CDY1BHTR1A | |
| SCHEMBL9125976 | 0.76 | CYP11B1 (0.32) | HTR1A | |
| SCHEMBL7353227 | 0.74 | HTR1A (0.64) | HTR1A | |
| SCHEMBL6354089 | 0.73 | HTR1A (0.56) | CDYLCDY1; CDY1BHTR1A | |
| SCHEMBL7351006 | 0.72 | HTR1A (0.65) | HTR1A | |
| SCHEMBL6361234 | 0.68 | DRD2 (0.61) | HTR1A | |
| SCHEMBL7343414 | 0.66 | HTR1A (0.40) | HTR1A | |
| SCHEMBL11620522 | 0.66 | FYN (0.59) | SIGMAR1FYNHTR1AHTR7ALDH1A1 | |
| SCHEMBL23261644 | 0.65 | HTR1A (0.49) | SIGMAR1FYNHTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |