Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777651 | 1.00 | ITGB1 (0.41) | ITGB1ITGA5KMT2AKDM4ETSHR | |
| SCHEMBL6777468 | 0.84 | ITGB3 (0.44) | ITGB1ITGA5KMT2AATML3MBTL1 | |
| SCHEMBL6783130 | 0.82 | ITGB1 (0.43) | ITGB1ITGA5KMT2AATML3MBTL1 | |
| SCHEMBL6773413 | 0.78 | ITGB3 (0.46) | ITGB1ITGA5KMT2ATSHRL3MBTL1 | |
| SCHEMBL6776549 | 0.78 | ITGB1 (0.42) | ITGB1ITGA5KMT2AATML3MBTL1 | |
| SCHEMBL6777344 | 0.77 | ITGB1 (0.51) | ITGB1ITGA5KMT2AATML3MBTL1 | |
| SCHEMBL7340558 | 0.77 | EPHX2 (0.39) | KMT2AKDM4ETSHREPHX2ATM | |
| SCHEMBL6774120 | 0.76 | ITGB3 (0.47) | ITGB1ITGA5 | |
| SCHEMBL8395852 | 0.75 | MAPK1 (0.55) | KMT2ACHRM3L3MBTL1HTT | |
| SCHEMBL6776873 | 0.75 | MEN1 (0.44) | ITGB1ITGA5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |