Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773948 | 0.84 | ITGB3 (0.43) | EPHX2KMT2AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6783139 | 0.83 | HTT (0.42) | EPHX2KMT2AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6773426 | 0.79 | MAPK1 (0.45) | EPHX2KDM4EKMT2AHTTL3MBTL1 | |
| SCHEMBL6776568 | 0.79 | HTT (0.39) | EPHX2KMT2AHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6777356 | 0.78 | ITGB1 (0.42) | EPHX2HTTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL6777651 | 0.77 | ITGB1 (0.41) | EPHX2ATMKDM4EKMT2AHTT | |
| SCHEMBL7340549 | 0.77 | ITGB1 (0.41) | EPHX2ATMKDM4EKMT2AHTT | |
| SCHEMBL7345600 | 0.76 | NPC1 (0.39) | EPHX2KDM4EKMT2ASMN1; SMN2POLB | |
| SCHEMBL8395852 | 0.75 | MAPK1 (0.55) | KMT2AHTTL3MBTL1NPC1RAB9A | |
| SCHEMBL7347508 | 0.75 | KMT2A (0.44) | KMT2AHPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |