Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349907 | 0.88 | ALDH1A1 (0.35) | ALDH1A1GAAMAPTHSD17B10RET | |
| SCHEMBL7345073 | 0.86 | ALDH1A1 (0.34) | ALDH1A1GAAMAPTHSD17B10RET | |
| SCHEMBL7342732 | 0.80 | MMP2 (0.40) | — | |
| SCHEMBL7344276 | 0.80 | PDE3B (0.42) | — | |
| SCHEMBL7338777 | 0.72 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL12116975 | 0.68 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTHSD17B10RET | |
| SCHEMBL4967534 | 0.67 | ALDH1A1 (0.53) | ALDH1A1GAAMAPTHSD17B10RET | |
| SCHEMBL4481502 | 0.65 | ALDH1A1 (0.50) | ALDH1A1GAAMAPTHSD17B10RET | |
| SCHEMBL21316386 | 0.64 | ADORA2A (0.38) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL7275955 | 0.64 | AKR1C4 (0.39) | ALDH1A1MAPTHSD17B10RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509845-A1 | (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-10-21 | — | — | EP | disclosed |
| US-5081242-A | Cardiotonic and bronchodilator agents; phosphodiesterase inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| US-4766118-A | CARDIOTONIC AGENTS, PHOSPHODIESTERASE INHIBITORS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0272914-A2 | 6-Benzoxazinyl- and 6-benzothiazinyl-2,3,4,5-tetrahydropyridazin-3-ones | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-06-29 | — | — | EP | disclosed |
| US-4721784-A | MUSCLE RELAXANTS, BRONCHODILATOR AGENTS, CARDIOTONIC AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-01-26 | — | — | US | disclosed |