SCHEMBL7340826

SCHEMBL7340826

CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1cccc2nsnc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 10/20 0.51
CACNA1F O60840 8/20 0.51
CACNA1D Q01668 8/20 0.51
CACNA1S Q13698 8/20 0.51
CYP1A2 P05177 5/20 0.50
NR1I2 O75469 3/20 0.50
ABCB11 O95342 3/20 0.50
NR3C1 P04150 3/20 0.50
ADORA3 P0DMS8 3/20 0.50
PDE4D Q08499 3/20 0.50
SCN5A Q14524 3/20 0.50
KCNH2 Q12809 2/20 0.50
PDE3A Q14432 2/20 0.50
LMNA P02545 2/20 0.50
PGR P06401 2/20 0.50
ABCB1 P08183 2/20 0.50
CNR1 P21554 2/20 0.50
ADRA1A P35348 2/20 0.50
SCN1A P35498 2/20 0.50
SCN2A Q99250 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7340281 0.87 CYP2C9 (0.50) CACNA1CCYP1A2NR1I2ABCB11NR3C1
SCHEMBL7340283 0.86 CYP2C9 (0.47) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7349734 0.84 CACNA1C (0.67) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL10914306 0.84 CYP2C9 (0.46) CACNA1CCYP1A2NR1I2ABCB11NR3C1
SCHEMBL10915270 0.84 KDM4E (0.45) CACNA1CCYP1A2NR1I2ABCB11NR3C1
SCHEMBL10914016 0.84 GAA (0.47) CACNA1CCYP1A2NR1I2ABCB11NR3C1
SCHEMBL10913383 0.84 GAA (0.47) CACNA1CCYP1A2NR1I2ABCB11NR3C1
SCHEMBL7348362 0.81 CYP2C9 (0.58) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL7344941 0.79 CACNA1C (0.76) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL11060276 0.78 ALDH1A1 (0.44) CACNA1DCYP1A2NR1I2ABCB11NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4466972-A HYPOTENSIVE, ANTIISCHEMIC, ANTISPASMODIC AGENTS SANDOZ LTD. (CH) 1984-08-21 US claimed