Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.56 |
| ▸ | F2 | P00734 | 4/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | TRHR | P34981 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299051 | 1.00 | PRSS1 (0.56) | PRSS1F2ACEOPRM1TRHR | |
| SCHEMBL7299046 | 1.00 | PRSS1 (0.56) | PRSS1F2ACEOPRM1TRHR | |
| SCHEMBL7295808 | 0.91 | F2 (0.52) | PRSS1F2ACEOPRM1 | |
| SCHEMBL7050971 | 0.91 | F2 (0.52) | PRSS1F2ACEOPRM1 | |
| SCHEMBL7113615 | 0.91 | F2 (0.52) | PRSS1F2ACEOPRM1 | |
| SCHEMBL7303710 | 0.86 | YAP1 (0.51) | PRSS1F2ACE | |
| SCHEMBL8072498 | 0.84 | ACE (0.57) | ACEOPRM1 | |
| SCHEMBL7346744 | 0.81 | F2 (0.54) | PRSS1F2 | |
| SCHEMBL7338542 | 0.81 | F2 (0.54) | PRSS1F2 | |
| SCHEMBL7340878 | 0.80 | F2 (0.60) | PRSS1F2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583146-A | Heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0601459-A2 | Sulfonamido heterocyclic thrombin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |