Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.57 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9897862 | 0.98 | OPRM1 (0.56) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL10038868 | 0.89 | OPRM1 (0.57) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL1822928 | 0.84 | OPRM1 (0.74) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| Hydrochloric Acid SCHEMBL28226628 | 0.82 | OPRM1 (0.71) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| SCHEMBL19104839 | 0.81 | OPRM1 (0.41) | OPRM1OPRL1OPRK1SLC6A4SLC6A3 | |
| SCHEMBL3407459 | 0.81 | VNN1 (0.40) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 | |
| Hydrochloric Acid SCHEMBL19094252 | 0.80 | OPRM1 (0.40) | OPRM1OPRL1OPRK1SLC6A4SLC6A3 | |
| SCHEMBL5036687 | 0.79 | OPRM1 (0.58) | OPRM1OPRL1OPRK1OGFRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28932379 | 0.78 | OPRM1 (0.56) | OPRM1OPRL1OPRK1OGFRL1ALDH1A1 | |
| SCHEMBL16678239 | 0.78 | OPRM1 (0.36) | OPRM1OPRL1OPRK1OGFRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649044-B1 | METHOD FOR SYNTHESISING SUBSTITUTED AMINOCYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| EP-2649044-B1 | METHOD FOR SYNTHESISING SUBSTITUTED AMINOCYCLOHEXANONE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2017-09-20 | — | — | EP | disclosed |
| US-8658827-B2 | Method for synthesizing substituted aminocyclohexanone compounds | GRUENENTHAL GMBH (DE) | 2014-02-25 | — | — | US | disclosed |
| EP-2649044-A1 | METHOD FOR SYNTHESISING SUBSTITUTED AMINOCYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2013-10-16 | — | — | EP | disclosed |
| EP-2041142-B1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| US-8399503-B2 | Spirocyclic azaindole derivatives | GRUENENTHAL GMBH (DE) | 2013-03-19 | — | — | US | disclosed |
| EP-2044016-B1 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | GRUENENTHAL GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| US-20120149914-A1 | Method for Synthesizing Substituted Aminocyclohexanone Compounds | GRUENENTHAL GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| US-20120149914-A1 | Method for Synthesizing Substituted Aminocyclohexanone Compounds | GRUENENTHAL GMBH (DE) | 2012-06-14 | — | — | US | disclosed |
| WO-2012076165-A1 | METHOD FOR SYNTHESISING SUBSTITUTED AMINOCYCLOHEXANONE DERIVATIVES | Grünenthal GmbH (DE) | 2012-06-14 | — | — | WO | disclosed |
| US-8138187-B2 | Substituted heteroaryl derivatives | GRUENENTHAL GMBH (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| US-20090156593-A1 | Spirocyclic Azaindole Derivatives | GRUNENTHAL GMBH (DE) | 2009-06-18 | — | — | US | disclosed |
| EP-2044016-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1-AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| EP-2041142-A1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008009416-A1 | SPIROCYCLIC AZAINDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
| WO-2008009415-A2 | 4-HETEROARYL-SUBSTITUTED 1-AMINOCYCLOHEXANE-1- AND CYCLOHEXENE-1-DERIVATIVES HAVING EFFECTS ON THE OPIOD RECEPTOR SYSTEM | Grünenthal GmbH (DE) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156593-A1 | Spirocyclic Azaindole Derivatives | AZI2, TPMT, AADAC | OPRM1 1869/4885OPRL1 2512/4885OPRK1 615/4885 |
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | OPRM1 1029/4885OPRL1 1562/4885OPRK1 532/4885 |
| US-20120149914-A1 | Method for Synthesizing Substituted Aminocyclohexanone Compounds | CCNK, WNK2, CDK2 | OPRM1 2335/4885OPRL1 3208/4885OPRK1 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.